Health Benefits

Cleveland Clinic Selects Guarino Extra Virgin Olive Oil for Research in Diet and Heart Health

Researchers Discover Extra Virgin Olive Oil May Prevent and Reduce Diet-Induced Heart Disease

Cleveland Clinic selected Guarino Extra Virgin Olive Oil for their ongoing clinical research study at the Cleveland Clinic Lerner Research Institute.  Their diet intervention study is designed to investigate the impact of a Mediterranean diet, specifically cold-pressed extra virgin olive oil (EVOO), on blood levels of specific metabolites recently linked to causing heart disease. 

Stanley Hazen, MD, PhD, Section Head of Preventative Cardiology and Rehabilitation at the Cleveland Clinic, served as principal investigator and author of clinical studies related to olive oil published in the New England Journal of Medicine and Nature Magazine.

Hazen recommends following the Mediterranean diet, which studies show can reduce cardiovascular disease.  According to Hazen, the key is also using first cold-press extra virgin olive oil instead of butter.  Less expensive olive oils are made with additional presses and steam heat which reduce the concentration of the ingredient in extra virgin olive oil identified to inhibit heart disease called DMB.

Here is an excerpt from a recent article published by the Cleveland Clinic titled Druggin Gut Flora to Prevent Heart Disease,  

Stanley Hazen, MD, PhD, and his team at Cleveland Clinic recently discovered that targeting microbes in the gut may prevent heart disease caused by a diet high in animal fats — a finding that represents a potential new approach for treating the leading cause of death in the United States.

Their novel approach centers around the team’s previous discovery of Trimethylamine N-oxide (TMAO), a byproduct formed in the gut during digestion of red meat, eggs and high-fat dairy products. Their research linked TMAO to atherosclerosis (hardening of the arteries) and heart disease, proving TMAO blood levels to be a powerful predictor of future heart attacks, stroke and death.

More recently, the team identified a naturally occurring inhibitor called 3,3-dimethyl-1-butanol (DMB) — found in extra-virgin olive oil, grape seed oil, some red wines and balsamic vinegar — that reduced TMAO blood levels and atherosclerosis in mice. But it’s the team’s approach, says Dr. Hazen, that really matters here.

“We were able to show that ‘drugging the microbiome’ is an effective way to block this type of diet-induced heart disease,” he says. “It’s much like how we use statins to inhibit cholesterol synthesis in human cells.I kind of like to think of this as a statin for microbes.”

Read more about Dr. Hazen’s study here

Hear Dr. Hazen discuss benefits of the Mediterranean Diet here.


Guarino extravirgin oil of sicily.
Guarino extravirgin oil of sicily.
Guarino extravirgin oil of sicily.